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KMID : 0882420120830030363
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Korean Journal of Medicine
2012 Volume.83 No. 3 p.363 ~ p.368
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A Case Report of Methimazole-Induced Acute Liver Failure Successfully Treated with Liver Transplantation
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Jeon Sung-Jin
Kim Tae-Yong
Lee Seung-Hoon
Kang Jong-Sik
Choi Gwang-Hyeon
Lee Seung-Gyu
Hwang Hee-Sang
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Abstract
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Antithyroid drugs inhibit the synthesis and excretion of thyroid hormone from the thyroid gland. Propylthiouracil (PTU) and methimazole are well known as antithyroid drugs. In 2011, the American Thyroid Association and American Association of Clinical Endocrinologists published management guidelines for hyperthyroidism and other causes of thyrotoxicosis, and recommended methimazole as the first-choice antithyroid drug for the treatment of hyperthyroidism. Lower hepatotoxicity is an advantage of methimazole. Fulminant hepatitis rarely occurs in methimazole users, and spontaneous recovery is expected even if it does occur. We describe a rare case of acute liver failure after methimazole intake in a 60-year-old man who underwent liver transplantation.
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KEYWORD
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Liver failure, Liver transplantation, Methimazole
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